Vegtrug RHP6002N Herb Garden, 80cm x 78cm x 58cm

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Mateo-Carrasco, H.; Gálvez-Contreras, M.C.; Fernández-Ginés, F.D.; Nguyen, T.V. Elevated liver enzymes resulting from an interaction between Raltegravir and Panax ginseng: A case report and brief review. Drug Metab. Drug Interact. 2012, 27, 171–175. [ Google Scholar] [ CrossRef] Epstein, R.J.; Leung, T.W.T.; Cheung, P.S.Y. Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy. Cancer Chemother. Pharmacol. 2006, 58, 835–837. [ Google Scholar] [ CrossRef] Khan, M.; Maryam, A.; Mehmood, T.; Zhang, Y.; Ma, T. Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals. Asian Pac. J. Cancer Prev. 2015, 16, 6831–6839. [ Google Scholar] [ CrossRef][ Green Version] Daveluy, A.; Géniaux, H.; Thibaud, L.; Mallaret, M.; Miremont-Salamé, G.; Haramburu, F. Probable Interaction Between an Oral Vitamin K Antagonist and Turmeric ( Curcuma longa). Therapie 2014, 69, 519–520. [ Google Scholar] [ CrossRef] [ PubMed] Markert, C.; Kastner, I.M.; Hellwig, R.; Kalafut, P.; Schweizer, Y.; Hoffmann, M.M.; Burhenne, J.; Weiss, J.; Mikus, G.; Haefeli, W.E. The Effect of Induction of CYP3A4 by St John’s Wort on Ambrisentan Plasma Pharmacokinetics in Volunteers of knownCYP2C19Genotype. Basic Clin. Pharmacol. Toxicol. 2014, 116, 423–428. [ Google Scholar] [ CrossRef] [ PubMed]

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Although current studies have already utilized real-world data to examine herb-drug interactions, there are further areas in which this research application can be improved. A case-control design, a commonly used approach in observational studies, is found not to be employed in herb-drug interaction studies utilizing real-world data in this review [ 37]. The inherent study limitations and the nature of case-control studies, detailed in Table 2, may significantly limit their utility in drug-herb assessments; however, this kind of design is suitable for investigating rare outcomes, latent outcomes, and multiple exposures [ 38]. Therefore, when appropriate, case-control studies can still be considered in the future for providing real-world evidence of herb-drug combinations. Murphy, P.A.; Kern, S.E.; Stanczyk, F.Z.; Westhoff, C.L. Interaction of St. John’s Wort with oral contraceptives: Effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contracept. 2005, 71, 402–408. [ Google Scholar] [ CrossRef] [ PubMed] Strippoli, S.; Lorusso, V.; Albano, A.; Guida, M. Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin. BMC Complement. Altern. Med. 2013, 13, 199. [ Google Scholar] [ CrossRef][ Green Version] Sturm, A.; Atreya, R.; Bettenworth, D.; Bokemeyer, B.; Dignaß, A.; Ehehalt, R.; Germer, C.; Grunert, P.C.; Helwig, U.; Herrlinger, K.; et al. S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn. Z. Für Gastroenterol. 2008, 46, 1094–1146. [ Google Scholar] Tamura, S.; Warabi, Y.; Matsubara, S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot (sweet clover) supplement. J. Clin. Pharm. Ther. 2012, 37, 724–725. [ Google Scholar] [ CrossRef] [ PubMed]